Table 5.
Upstream regulator analysis identified molecules.
| Upstream Regulator | Molecule Type | Predicted Activation State | z-score | Target molecules in dataset | |
|---|---|---|---|---|---|
| Multibacillary | IFNG | cytokine | Inhibited | −3.6 | C1QA,CYBB,FABP5,FGL2,HLA-B,HLA-DOB,IFIT2,JUN,P2RY14,RARRES1,S100A8, S100A9,TGM1,TJP1,TNFAIP6,TNFSF13B |
| IL1B | cytokine | Inhibited | −2.6 | CYBB,FABP5,FST,JUN,S100A8,S100A9, TGM1,TJP1,TNFAIP6,TNFSF13B | |
| OSM | cytokine | Inhibited | −2.4 | GCA,GPNMB,HLA-B,JUN,MARCKS,RAB31,S100A12,S100A8,S100A9 | |
| Interferon alpha | group | Inhibited | −2.2 | HLA-B,IFIT2,S100A9,TGM1,TNFSF13B | |
| TGFB1 | growth factor | Inhibited | −2.1 | C1QA,CXCR6,CYBB,FABP5,FILIP1L,JUN,MXI1,P2RY14,RAB31,TNFAIP6,TNFSF13B | |
| TGM2 | enzyme | Inhibited | −2.0 | GCA,HLA-B,IFIT2,S100A8 | |
| CREB1 | transcription regulator | Inhibited | −2.0 | CRYM,FGL2,GPNMB,JUN,KLF5 | |
| PRKCA | kinase | Inhibited | −2.0 | CYBB,IGF2BP3,JUN,S100A8,S100A9 | |
| IL1A | cytokine | Inhibited | −2.0 | JUN,S100A12,S100A8,S100A9 | |
| IGF1 | growth factor | Inhibited | −2.0 | C1QA,CYBB,JUN,TJP1 | |
| TNF | cytokine | Inhibited | −2.0 | CYBB,FABP5,FST,HLA-B,JUN,KLF5,MAGI1,S100A8,S100A9,TBC1D8,TJP1,TNFAIP6,TNFSF13B,TNS3 | |
| HOXA10 | transcription regulator | Activated | 2.0 | CYBB,FST,S100A12,TNFSF13B | |
| Immunoglobulin | complex | Activated | 2.0 | RAB31,S100A12,S100A8,S100A9 | |
| Paucibacillary | NEUROG1 | transcription regulator | Inhibited | −2.0 | FABP3,ITGB3,PPIC,TSPAN7 |
| TP53 | transcription regulator | 2.0 | ACTA2,CLU,CTSH,DTX1,FABP3,HLA-B,ITGB5,PAWR,PLA2G16,PPIC,PSMD8,SH3BGRL2,TJP1,VCAN | ||
| PGR | ligand-dependent nuclear receptor | 2.0 | AKR1C3,CEBPD,GSTM3,VCAN | ||
| EDN1 | cytokine | 2.0 | ACTA2,ITGB3,OLR1,VCAN | ||
| BRD4 | kinase | 2.0 | ACTA2,HBD,ITGB5,PDGFC | ||
| CEBPB | transcription regulator | 2.0 | ACTA2,AKR1C3,CD14,CEBPD,CFD,PDK4,VCAN | ||
| CXCL12 | cytokine | Activated | 2.2 | ACTA2,AKR1C3,CD14,CXCR6,ITGB3 | |
| RAF1 | kinase | Activated | 2.2 | CTSH,DCBLD2,ITGB3,ITGB5,SELENBP1 | |
| ERK | group | Activated | 2.2 | CEBPD,CLU,ITGB3,PDGFC,PDK4,VCAN | |
| AKT1 | kinase | Activated | 2.2 | ACTA2,CEBPD,CLU,MYH11,VCAN | |
| APP | other | Activated | 2.6 | ACTA2,CLU,CRYL1,FABP3,GSTM3,ITGB3,MAP2,OLR1,SHISA3,TJP1,VCAN | |
| Resilient | IL1B | cytokine | Inhibited | −3.1 | A2M,CYBB,HNF4A,OLR1,PTGS2,S100A9,THBS1,TIMP2,TJP1,TNFSF13B,VCAN |
| IFNG | cytokine | Inhibited | −2.6 | A2M,CYBB,PTGS2,S100A9,THBS1,TJP1,TNFSF13B | |
| TNF | cytokine | Inhibited | −2.4 | A2M,CYBB,HNF4A,KLF5,OLR1,PTGS2,S100A9,THBS1,TIMP2,TJP1,TNFSF13B,TNS3 | |
| CREB1 | transcription regulator | Inhibited | −2.2 | CRYM,GPNMB,KLF5,NNAT,PTGS2 | |
| P38 MAPK | group | Inhibited | −2.2 | CYBB,KLF5,PTGS2,THBS1,TIMP2 | |
| TGFB1 | growth factor | Inhibited | −2.2 | CYBB,HNF4A,OLR1,PTGS2,THBS1,TIMP2,TNFSF13B,VCAN | |
| EDN1 | cytokine | Inhibited | −2.2 | CYBB,OLR1,PTGS2,THBS1,VCAN | |
| PI3K (complex) | complex | −2.0 | CYBB,MAP2,PTGS2,THBS1 | ||
| ERK | group | −2.0 | KLF5,PTGS2,THBS1,VCAN | ||
| PPARA | ligand-dependent nuclear receptor | −2.0 | CYBB,FABP3,HNF4A,PTGS2,TJP1 |