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. 2019 Jun 4;9:8254. doi: 10.1038/s41598-019-44765-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genes that showed consistent longitudinal differential expression in SALS twins included known ALS genes. (A) Seven hundred and fifty genes were identified as differentially expressed with a minimum fold change of 1.5 (vertical lines) and significant FDR-corrected p-value (horizontal line) in the male SALS twins. (B) Expression of two previously reported ALS genes, CCNF and CCS, identified as differentially expressed in male SALS twins. Gene expression is shown for all three collections in each twin. (C) Expression of the top 8 genes (as ranked by limma) are shown for all three longitudinal collections of the male SALS twins.