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. 2019 Jun 4;10(6):435. doi: 10.1038/s41419-019-1659-1

Fig. 4. SPINT2 level was significantly downregulated by STYK1 overexpression both in vivo and in vitro.

Fig. 4

a KEGG pathway analysis based on the RNA-seq results for NC vs. STYK1 OE in H1299 cells. P-value was corrected by FDR, and the FDR < 0.01 was considered to be significantly enriched. b Representative Scatter Plot of 134 significant genes (20 upregulated genes marked in red and 114 downregulated genes marked in blue) for NC vs. STYK1 OE. c Representative heatmap of gene expression levels. d Representative FPKM value of SPINT2 in three replicates of the NC and STYK1 OE groups. e mRNA levels of SPINT2 measured by qRT-PCR were shown. f Representative western blot result of SPINT2 levels. Membranes were re-probed for β-actin expression to show that similar amounts of protein were loaded in each lane. *P < 0.05 vs. the NC group