Figure 2.

SOD1 binds to DNA with different sequence preferences under varied redox conditions. (A) Person correlations between parallel ChIP-Seq samples in control (designed as C1, C2 and C3), H₂O₂ (H1, H2 and H3), and LD100 (L1, L2 and L3) treated groups. Unless otherwise specified, the labels for all ChIP-Seq samples were the same as here. All the ChIP-Seq data were representative of three independent experiments. (B) Typical SOD1 binding motifs under varied redox conditions. (C) Motif logo matching between motif A (bottom) and four consensus motifs (top), determined by TOMTOM (MEME). (D and E) Hierarchical clustering analyses of fold enrichment values in control, H₂O₂ and LD100 treated groups. (F–H) Enriched GO terms of all ChIP-Seq samples in control (F), H₂O₂ (G), and LD100 treated groups (H).