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. 2019 Jun 4;9:8287. doi: 10.1038/s41598-019-44599-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Coverage plots showing examples of isolates with three types of gch1 duplications. (A) No duplication in a Cambodian isolate. (B) Promoter duplication in a Malawian isolate. (C) Gene Duplication in a Cameroon isolate; Blue traces represent the per base coverage for each isolate. Orange region indicates the predicted structural variant; Green region indicates the gene of interest, Grey indicates neighbouring genes; horizontal line is the median coverage for the isolate.