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. 2019 Apr 23;216(6):1377–1395. doi: 10.1084/jem.20181394

Figure 6.

Figure 6.

Lamin B1 and RET expression show inverse correlation in lung cancer patients. (A) IHC of representative tissue samples from different types and grades of lung tumors, from a tissue microarray, stained with an anti-RET antibody. Scale bars, 25 µm. (B) Relative RET staining intensity (H-score) in lung tumors of different types and grades. n = 70 adenocarcinoma (20 grade 1, 30 grade 2, 20 grade 3); n = 69 SCC (16 grade 1, 33 grade 2, 20 grade 3); n = 22 SCLC; and n = 20 normal lung tissue (NL). ***, P < 0.001 versus normal lung tissue. #, P < 0.05. AD, adenocarcinoma. (C) Correlation between the relative staining intensity for lamin B1 and RET; r, Pearson correlation coefficient. (D) Coimmunostaining of representative adenocarcinoma and SCC grade 3 samples with RET and lamin B1 antibodies showing that cells highly positive for lamin B1 express low levels of RET and vice versa. Scale bars, 50 µm.