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. 2019 May 3;216(6):1450–1464. doi: 10.1084/jem.20182376

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© 2019 Kotov et al.

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Figure 2. — BCOR is important for the induction of canonical Th17 cell–associated chemokine receptor and cytokine expression. WT and BCOR-deficient mice were infected with Sp-2W bacteria, and 2W:I-A^b-specific CD4⁺ T cells from spleen and cervical lymph nodes were analyzed 7 d later. IL-17A production was assessed 2 h following 2W peptide injection. (A) CCR6 expression by 2W:I-A^b–specific Th17 (RORγt⁺ CXCR5⁻) and Tfh (RORγt⁻ CXCR5⁺) cells. (B) CCR6 percentage of each subset from individual mice identified as in A with horizontal bars at the means. (C) IL-17A secretion by 2W:I-A^b–specific subsets. (D) IL-17A percentage of each subset from individual mice with horizontal bars at the means. Numbers in flow cytometry plots indicate percentages of gated populations. Data shown in all panels are representative of two independent experiments (n = 2–9 mice per group). Student’s t test; ***, P < 0.001.