Table I.
Cox regression analysis indicated a direct association between the risk of progression and fatality with baseline values of neutrophil and lymphocyte counts, ESR and LDH.
| PFS | OS | |||
|---|---|---|---|---|
| Variables at baseline (units) | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Neutrophil cell counts (103/mm3) | 1.13 (1.01–1.26) | 0.04 | 1.14 (1.003–1.29) | 0.04 |
| Lymphocytes cell count (103/mm3) | 1.14 (0.98–1.31) | 0.08 | 1.19 (1.02–1.40) | 0.03 |
| ESR (mm/h) | 1.03 (1.01–1.04) | 0.002 | 1.04 (1.02–1.06) | 0.001 |
| LDH (20 U/l) | 1.04 (1.02–1.06) | <0.001 | 1.04 (1.01–1.06) | 0.001 |
PFS, progression free survival; OS, overall survival; ESR, erythrocyte sedimentation rate; LDH, lactic acid dehydrogenase; CI, confidence interval; HR, hazard ratio.