Table II.
Cox regression analysis indicated a direct association between the risk of progression and fatality with changes (Delta of values at three treatment courses vs. baseline) in neutrophil counts and NLR, and an inverse correlation of the risk of both outcomes with changes in eosinophil and lymphocyte counts.
| PFS | OS | |||
|---|---|---|---|---|
| Variables at the third treatment course (units) | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Neutrophil cell counts (103/mm3) | 1.13 (1.03–1.24) | 0.009 | 1.16 (1.04–1.29) | 0.007 |
| Lymphocytes cell count (103/mm3) | 0.79 (0.63–1.00) | 0.05 | 0.71 (0.55–0.91) | 0.007 |
| Eosinophil cell counts (103/mm3) | 0.008 (0.00–0.23) | 0.005 | 0.03 (0.001–0.771) | 0.04 |
| NLR | 1.19 (1.06–1.34) | 0.005 | 1.27 (1.10–1.46) | 0.001 |
Change in ESR and LDH were unrelated to the outcomes. PFS, progression free survival; OS, overall survival; NLR, neutrophil lymphocyte ratio; ESR, erythrocyte sedimentation rate; LDH, lactic acid dehydrogenase; CI, confidence interval; HR, hazard ratio.