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. 2019 May 30;177(6):1619–1631.e21. doi: 10.1016/j.cell.2019.04.013

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© 2019 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Model of the First mRNA Deadenylation Step

(A) Side and top views of the pseudo-atomic model of the Pan2-Pan3-90A RNP complex. The difference density (black mesh) shows the path of the poly(A) RNA (compare also Figure 3C).

(B) The schematic depicts how Pan2-Pan3 carries out the first deadenylation step by recognizing a long poly(A) RNP, shortening and eventually releasing it when it contains only a single Pab1 protomer. The drawing recapitulates the features observed in the cryo-EM structure and integrates them with the results from the biochemical characterization.