FIGURE 2.

Transcriptome analysis (RNA-seq) of genes differently expressed in Rom^R clone compared to HG001 wild type strain. (A) The Venn diagrams show numbers of genes that are at least fourfold up- or downregulated after 4 and 8 h of growth in BM in the Rom^R clone. (B) Percentage of genes being at least fourfold up (red bars) or downregulated (blue bars) in each of cluster orthologous groups (COG) based on functional categories. Designations of functional categories: C, energy production and conversion; D, cell division and chromosome partitioning; E, amino acid metabolism and transport; F, nucleotide metabolism and transport; G, carbohydrate metabolism and transport; H, coenzyme metabolism; I, lipid metabolism; J, translation, ribosomal structure and biogenesis; K, transcription; L, DNA replication, recombination, and repair; M, cell wall structure and biogenesis, outer membrane; N, Cell motility and chemotaxis; O, post-translational modification, protein turnover, chaperone functions; P, Inorganic ion transport and metabolism; Q, secondary metabolites biosynthesis, transport and catabolism; R, general functional prediction; T, signal transduction mechanisms; U, secretion; V, defense mechanisms.