FIGURE 6.

Model for FarE mediated resistance to Rom in the Rom^R clone. In the Rom^R clone farR is inactivated by the point mutation that leads to an amino acid exchange (Cys116/Arg) in the FarR regulator protein. FarR, acts not only as a repressor of its own farR gene but also represses farE. The mutation in farR indicated by (^∗) leads to inactivation of FarR and consequently to derepression of farE and many other genes (including farR, agr, sarA, hla, psm-α,β, hld, geh). Derepression of farE causes over-expression of FarE. We propose that FarE acts as an exporter of lipids that interact with Rom thus causing neutralization of Rom and leading to high Rom resistance.