Table 3.
Selected annotated genes that are up- or down-regulated in RomR clone1.
| Gene2 | Function | Ratio RomR/WT |
|
|---|---|---|---|
| 4 h | 8 h | ||
| Regulators | |||
| SAOUHSC_02867 | FarR-regulator protein (farR) | 5.40 | 18.27 |
| SAOUHSC_02261 | Accessory gene regulator protein B (agrB) | 1.51 | 5.83 |
| SAOUHSC_02260 | Delta hemolysin (hld), RNAIII | 17.66 | n.d. |
| SAOUHSC_00620 | Accessory regulator A (sarA) | 1.56 | 3.77 |
| SAOUHSC_00666 | Glycopeptide resistance-associated two-component system, GraS (graS) and | 0.61 | 0.08 |
| SAOUHSC_00665 | GraR (graR) | 0.49 | 0.11 |
| Secreted toxins, enzymes and transporters | |||
| SAOUHSC_01121 | Alpha-hemolysin (hla) | 0.7 | 97.5 |
| SAOUHSC_01135 | Phenol-soluble modulin beta1 (psmß1) | 231.1 | 1113.5 |
| SAOUHSC_03006 | Lipase (SAL1) (gehA) | 0.33 | 127.7 |
| SAOUHSC_00987 | Cysteine protease, staphopain B (sspB) | 1.44 | 7.30 |
| SAOUHSC_02866 | FarE, fatty acid efflux pump (farE) | 19.46 | 92.82 |
| SAOUHSC_02874 | Cation transporter E1-E2 family ATPase | 4.25 | 5.75 |
| SAOUHSC_01193 | Fatty acid kinase (fakA) | 0.46 | 0.15 |
| SAOUHSC_00764 | FA-binding protein, binds saturated FA (fakB1) | 0.89 | 0.07 |
| SAOUHSC_01433 | FA-binding protein, prefers unsaturated FA (fakB2) | 0.28 | 4.38 |
| Capsular proteins | |||
| SAOUHSC_00114 | Capsular polysaccharide biosynthesis protein | 0.94 | 32.25 |
| SAOUHSC_00115 | Capsular polysaccharide biosynthesis Cap5B | 1.47 | 11.82 |
| SAOUHSC_00116 | Capsular polysaccharide biosynthesis Cap8C | 2.99 | 12.46 |
| Cell wall bound proteins | |||
| SAOUHSC_00069 | Protein A (spa) | 1.03 | 0.08 |
| SAOUHSC_01175 | Fibrinogen-binding protein A-like protein (sdrA) | 0.62 | 0.15 |
| SAOUHSC_00544 | Fibrinogen-binding protein SdrC (sdrC) | 0.16 | 0.09 |
| SAOUHSC_00545 | Fibrinogen-binding protein SdrD (sdrD) | 0.37 | 0.09 |
| SAOUHSC_02855 | LysM domain-containing protein | 0.20 | 0.01 |
1Transcriptome data analysis is based on the NCBI RefSeq annotation of Staphylococcus aureus NCTC 8325, the progenitor strain of HG001. 2Total genes are listed in Supplementary Table S1. Gene names were obtained from AureoWiki (Fuchs et al., 2018). n.d, not determined.