Table 3.
Chemical and biological parameters of the investigated OPCs.
| Organophosphorus compound | Molecular weight | IC50 (μM) | LD50 (μmol/rat) | LD70 (μmol/rat) | Injected dose (μmol/rat) |
|---|---|---|---|---|---|
| DFP | 184.15 | 0.12 | 4.8 | 6 | 6, 10, 14 |
| Ethyl-paraoxon | 275.2 | 0.015 | 0.8 | 1 | 1, 5, 10 |
| Methyl-paraoxon | 247.14 | 0.06 | 1.1 | 1.5 | 2, 3, 5 |
| Azinphos methyl | 317.32 | 189 | 3.2 | 5 | 5, 10, 15 |
Column 2 lists their molecular weights, column 3 their concentration necessary to inhibit 50% of human red blood cell AChE activity (IC50), column 4 their LD50 values for intraperitoneal (i.p). application in rats, column 5 their LD70 values, and column 6 the doses injected i.p. to perform a Cox (1972) analysis of the mortality-reducing efficacy of various oximes, including K027. The administered doses are approximately LD70, LD100, and twice LD70.