Table 3.
Subgroup analysis of circRNAs in various cancer types.
| Subgroup analysis | Studies (n) | CircRNA | HR | 95% CI | p-value | Heterogeneity | ||
|---|---|---|---|---|---|---|---|---|
| I2 (%) | PQ | Model | ||||||
| Gastric cancer | Chen et al. (2017) | circPVT1 | 0.508 | 0.347-0.745 | ||||
| Zhang et al. (2017) | circLARP4 | 0.689 | 0.552 -0.860 | |||||
| Total | 0.621 | 0.500-0.743 | 0.000 | 49.6% | 0.159 | Fixed | ||
| Colorectal cancer | Hsiao et al. (2017) | circCCDC66 | 2.266 | 1.265-4.061 | ||||
| Weng et al. (2018) | ciRS-7 | 2.441 | 1.298-4.594 | |||||
| Zeng et al. (2017) | circHIPK3 | 3.047 | 1.525 -5.147 | |||||
| Total | 2.518 | 1.608 -3.429 | 0.000 | 0.0% | 0.809 | Fixed | ||
| Hepatocellular carcinoma | Han et al. (2017) | circMTO1 | 0.491 | 0.349 -0.691 | ||||
| Zhang et al. (2018) | circ_0001649 | 0.265 | 0.141-0.498 | |||||
| Meng et al. (2018) | circ_10720 | 4.300 | 1.495-6.984 | |||||
| Xu et al. (2017) | circCdr1as | 3.621 | 2.108-5.325 | |||||
| Guo et al. (2017) | circITCH | 0.512 | 0.320-0.781 | |||||
| Zhu et al. (2018) | circ_0067934 | 3.605 | 1.816-5.546 | |||||
| Total | 0.441 | 0.333-0.549 | 0.000 | 86.9% | 0.000 | Random | ||
| Breast cancer | He et al. (2017) | circGFRA1 | 3.790 | 2.011-7.142 | ||||
| Wu et al. (2018) | circIRAK3 | 3.328 | 1.208-5.234 | |||||
| Total | 3.474 | 1.947-5.000 | 0.000 | 0.0% | 0.764 | Fixed | ||
| Bladder cancer | Yang et al. (2018) | circITCH | 0.480 | 0.236-0.976 | ||||
| Zhong et al. (2017) | circMYLK | 2.595 | 1.010-6.668 | |||||
| Okholm et al. (2017) | circHIPK3 | 0.406 | 0.220-0.750 | |||||
| Okholm et al. (2017) | circCDYL | 0.533 | 0.325-0.780 | |||||
| Li et al. (2017) | circHIPK3 | 4.325 | 2.800-6.907 | |||||
| Total | 0.490 | 0.332-0.654 | 0.000 | 71.0% | 0.008 | Random | ||
| Lung cancer | Liu et al. (2018) | circ_103809 | 2.494 | 1.036-6.005 | ||||
| Yao et al. (2017) | circ_100876 | 2.731 | 1.709-4.363 | |||||
| Zhao et al. (2017) | circFADS2 | 3.232 | 1.495-6.984 | |||||
| Wang et al. (2018) | circ_0067934 | 3.774 | 1.498-6.670 | |||||
| Total | 2.913 | 1.919-3.907 | 0.000 | 0.0% | 0.883 | Fixed | ||
| Osteosarcoma | Wu et al. (2018) | circ_0002052 | 0.406 | 0.220-0.750 | ||||
| Ma et al. (2018) | circHIPK3 | 0.461 | 0.218-0.977 | |||||
| Zhou et al. (2018) | circ-0008717 | 2.729 | 1.100-6.773 | |||||
| Zhu et al. (2018) | circPVT1 | 3.306 | 1.663-6.570 | |||||
| Zhang et al. (2017) | circUBAP2 | 2.364 | 1.275-4.382 | |||||
| Total | 0.496 | 0.282-0.710 | 0.000 | 70.3% | 0.009 | Random | ||
Abbreviations: HR, hazard ratio; CI, confidence interval.