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Schematic diagram of the mechanism proposed in this research. NONHSAT076754 was overexpressed in EOC. NONHAT076754 knockdown markedly inhibited EOC invasion and metastasis in vitro and in vivo. Mechanically, two metastasis-related genes PTEN and HTATIP2 might participate in NONHSAT076754-mediated pro-metastatic effect. Further rescue assays validated that knockdown of HTATIP2 remarkably reversed NONHAT076754 silencer-induced inhibition of EOC cell metastasis.
