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. 2019 Mar 3;10(7):1616–1621. doi: 10.7150/jca.28218

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Estrogen receptor alpha is necessary for estrogen enhancing endometrial cancer proliferation via prohibitin. The effect of ICI on estrogen-induced prohibitin expression is determined by western blot (A) and the statistical analysis of changes of prohibitin protein (B). *P<0.05, compared with control. Transfection pcDNA-ERɑ plasmid (1μg) enhances estrogen-induced prohibitin expression (C) and the statistical analysis of changes of prohibitin protein (D). *P<0.05, compared with control. (E) Transfection of pcDNA-ERɑ plasmid (1μg) enhances estrogen-induced endometrial cancer proliferative activity. *P<0.05, compared with control.