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. 2019 Feb 28;10(7):1601–1610. doi: 10.7150/jca.27261

Figure 5.

Figure 5

Combination of c-Myb and COX-2 in predicting prognosis of CRC in stage II and III patients. A and B) Combination of both up-regulated molecules predicted worse overall survival in stage Ⅱ patients without (A; log-rank; p = 0.748 for subgroup 2 and p = 0.193 for subgroup 3, respectively) or with 5-Fu based chemotherapy (B; log-rank; p = 0.412 for subgroup 2 and p = 0.028 for subgroup 3, respectively). C and D) Combination of both up-regulated molecules predicted worse overall survival in stage Ⅲ patients without (C; log-rank; p = 0.029 for subgroup 2 and p = 0.349 for subgroup 3, respectively) or with 5-Fu based chemotherapy (D; log-rank; p < 0.001 for subgroup 2 and p < 0.001 for subgroup 3, respectively). Subgroup 1, low c-Myb and low COX-2; subgroup 2, (low c-Myb and high COX-2) or (high c-Myb and low COX-2); subgroup 3, high c-Myb and high COX-2. Subgroup 1 was chosen as control.