Table 2.
The effects of clinicopathologic variables on overall survival rate by univariate and multivariate Cox proportional hazard regression analysis
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| c-Myb | 2.693 | 1.640 - 4.421 | < 0.001 | 1.841 | 1.082 - 3.133 | 0.024 |
| COX-2 | 2.334 | 1.485 - 3.669 | < 0.001 | 1.672 | 1.022 - 2.736 | 0.041 |
| Age | 1.033 | 0.643 - 1.661 | 0.892 | |||
| Gender | 0.957 | 0.621 - 1.476 | 0.843 | |||
| Tumor location | 0.910 | 0.698 - 1.185 | 0.482 | |||
| Differentiation | 2.348 | 1.272 - 4.333 | 0.006 | 1.409 | 0.749 - 2.651 | 0.288 |
| Tumor size | 1.192 | 0.775 - 1.833 | 0.425 | |||
| Depth of invasion | 4.324 | 1.365 - 13.698 | 0.013 | 1.995 | 0.612 -6.500 | 0.252 |
| Lymph node involvement | 4.000 | 2.545 - 6.286 | < 0.001 | 3.535 | 1.127 - 11.084 | 0.030 |
| Distant metastatic spread | 3.407 | 1.752 - 6.623 | < 0.001 | 2.247 | 1.014 - 4.978 | 0.046 |
| TNM stage | 2.637 | 1.975 - 3.520 | < 0.001 | 0.945 | 0.285 - 3.134 | 0.927 |
| 5-Fu-based chemotherapy | 1.038 | 0.674 - 1.598 | 0.865 | |||
| KI-67 expression | 1.212 | 0.762 - 1.928 | 0.417 | |||
| TP53 status | 1.318 | 0.814 - 2.135 | 0.262 | |||
| CEA status | 1.583 | 1.019 - 2.458 | 0.041 | 1.258 | 0.795 - 1.990 | 0.326 |
Abbreviations: TNM, tumor node metastasis; HR, hazard ratio; CI, confidence interval.