Table 2.

Dopamine receptors agonist or antagonist function as an inhibitor of cancer.

Substance	Targets	Activation or inhibition of dopamine receptor	Type of cancers	References
A77636	DRD1	active	breast cancer	88
Fenoldopam	DRD1	active	breast cancer	96
SKF82958	DRD1	active	ovarian	89
SKF38393	DRD1	active	osteosarcoma	37, 87
SCH39166	DRD1, DRD5	inhibit	colorectal cancer	84
BIM53097	DRD2	active	pituitary	92, 93
Bromocriptine	DRD2	active	breast cancer	73
			aldosterone-producing adenoma	74
			hepatic carcinoma	75
			prolactinomas	76
Fisetin	DRD2	active	hepatic carcinoma	72
Haloperidol	DRD2	inhibit	pituitary	34
			prostate cancer	95
L-741,626	DRD2	inhibit	colorectal cancer	84
Olanzapine	DRD2	inhibit	glioblastoma	117, 118
			lung cancer	119
			pancreatic cancer	119
PG01037	DRD2	inhibit	colorectal cancer	84
Pimozide	DRD2	inhibit	pancreatic cancer	40
			prostate cancer	120
			glioblastoma	121
Quinpirole	DRD2	active	gastric cancer	69
			small lung cancer	70
			non small lung cancer	71
Sertindole	DRD2	inhibit	neuroblastoma	47
Sulpiride	DRD2	inhibit	breast cancer	85
Thioridazine	DRD2	inhibit	AML	78
			breast cancer	77
			cervical cancer	38, 39
			hepatic carcinoma	94
			ovarian cancer	53, 79, 80
Trifluoperazine	DRD2	inhibit	prostate cancer	95
			glioblastoma	81
			lung cancer	82
Pramipexole	DRD2, DRD3	active	adrenal pheochromocytoma	52
			neuroblastoma	52
Quinpirole	DRD2, DRD3	active	adrenal pheochromocytoma	52
			neuroblastoma	52
7-oh-PIPAT	DRD3	active	MPNST	43
L-741,742	DRD4	inhibit	GNS	31
SKF83959	DRD5	active	pituitary tumor	44
			gastric cancer	44
Clozapine	DRs	inhibit	AML	78
Chlorpromazine	DRs	inhibit	AML	78