Table 3.
Meta-analysis of DBC1 overexpression classified by clinicopathological parameters
| Study covariates | Studies (patients) | OR (95% CI) | I2 (%) | Ph | Z | P | Model |
|---|---|---|---|---|---|---|---|
| Gender (Female/Male) | 9(2391) | 0.878(0.723-1.066) | 0.0 | 0.565 | 1.32 | 0.188 | fixed |
| Age (<60/≥60) | 5(1121) | 0.596 (0.467-0.761) | 3.5 | 0.387 | 4.14 | <0.001 | fixed |
| WHO classification (Tubular/Others) | 2(373) | 3.780(2.303-6.205) | 0.0 | 0.348 | 5.26 | <0.001 | fixed |
| Lauren classification (Intestinal/Diffuse) | 3(770) | 2.000(1.492-2.680) | 0.0 | 0.768 | 4.64 | <0.001 | fixed |
| LN metastasis (Absence/Presence) | 5(1064) | 0.405(0.203-0.806) | 85.6 | <0.001 | 2.57 | 0.010 | random |
| Distant metastasis (Absence/Presence) | 4(1270) | 1.421(0.885-2.282) | 0.0 | 0.755 | 1.45 | 0.146 | fixed |
| Tumor size (≤5/>5cm) | 2(321) | 0.698(0.153-3.184) | 85.3 | 0.009 | 0.46 | 0.642 | random |
| TNM stage (1-2/3-4) | 9(2391) | 0.737(0.474-1.147) | 87.1 | <0.001 | 1.56 | 0.119 | random |
| Tumor invasion (Early cancer/Advanced cancer) | 3(713) | 0.488(0.195-1.222) | 83.8 | 0.002 | 1.53 | 0.126 | random |
| Venous invasion (Absence/Presence) | 3(921) | 0.590(0.188-1.848) | 84.8 | 0.001 | 0.91 | 0.365 | random |
| Histologic grade (well+ moderately differentiated/ poorly differentiated) | 8(2192) | 0.854(0.511-1.429) | 76.2 | <0.001 | 0.60 | 0.548 | random |
LN lymph node; OR odds ratio; CI confidence intervals; Ph P-value for heterogeneity based on Q test; P P-value for statistical significance based on Z test.