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Diagram of the mechanism by which TEA regulates the NLRP3 inflammasome. Adriamycin induces oxidative stress by increasing the overproduction of ROS. ERK1/2 kinases mediate ROS-triggered activation of the NLRP3 inflammasome. TEA reduces NLPR3 via suppression of ERK1/2 kinases and subsequently inhibits the NLRP3 inflammasome activation induced by Adriamycin. Thus, TEA ameliorates Adriamycin-induced renal tubule injury via suppression of ROS-ERK1/2-mediated NLRP3 priming process.
