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. 2019 May 28;10:567. doi: 10.3389/fphar.2019.00567

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Copyright © 2019 Li, He, Xia, Sun, Shi, Zhou, Zhu, Zhang, Liu, Zhu, Zhu, Zhou, Sun and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TEA attenuates proteinuria and improves hypoproteinemia in rats with Adriamycin nephropathy. (A) Experimental procedure. The ADR and TEA groups underwent right nephrectomy on day 7 and ADR was injected through the tail vein on days 14 and 21. The rats were sacrificed on day 28. TEA was given by gavage once a day at a dosage of 1.5 g/kg/d in the treatment group. Rats in the model group received 2 mL normal saline by gavage daily from day 14. Comparisons of urinary protein (B), blood albumin (C), and serum creatinine (D) levels among the 3 groups (means ± SD) (^∗P < 0.05 between groups).