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. 2019 May 28;11:124. doi: 10.3389/fnagi.2019.00124

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Copyright © 2019 Sun, Ju, Wang, Zhang, Ding, Zhang, An, Sun, Li, Lu, Zhang and Chi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated circulating Th17 populations in AD rats. The population of Th17, a subset percent of total CD4+ T cells, was estimated with use of flow cytometry. Dot plots shown are representative of rats in the Control (A), AD7d (B), and AD14d (C) groups. Th17 cells were confirmed as CD4⁺IL-17⁺IFN-γ^- cells. Numbers in each compartment indicate the proportions of Th17 and Th1 in CD4⁺ cells. (D) Percent of Th17 in total CD4+ T cells in the Control, AD7d and AD14d groups. n = 9 per group, mean ± standard deviation, ^∗P < 0.05, ^∗∗∗P < 0.001 vs. Control group, #P < 0.05 vs. AD7d group.