Table 1.
Association of EZH2 and Bcl-2 expression with clinicopathologic parameters in test cohort DLBCL patients.
| Variables | All cases |
EZH2 | P | Bcl-2 | P | EZH2/Bcl-2 coexpression |
P |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| High | Low | High | Low | Yes | No | |||||
| Age (years) ≤60 >60 |
64 21 |
37 15 |
27 6 |
0.267 | 36 16 |
28 5 |
0.104 | 26 13 |
38 8 |
0.089 |
| Gender Male Female |
56 29 |
37 15 |
19 14 |
0.198 | 32 20 |
24 9 |
0.289 | 26 13 |
30 16 |
0.888 |
| ECOG <2 ≥2 |
78 7 |
48 4 |
30 3 |
1.000 | 48 4 |
30 3 |
1.000 | 36 3 |
42 4 |
1.000 |
| B symptom Yes No |
37 48 |
29 23 |
8 25 |
0.004 | 25 27 |
12 21 |
0.288 | 22 17 |
15 31 |
0.027 |
| Extranodal sites <2 ≥2 |
68 17 |
40 12 |
28 5 |
0.373 | 43 9 |
25 8 |
0.436 | 32 7 |
36 10 |
0.663 |
| LDH Normal Elevated |
33 52 |
16 36 |
17 16 |
0.056 | 17 35 |
16 17 |
0.145 | 11 28 |
22 24 |
0.064 |
| Ann-Arbor stage Ⅰ-Ⅱ Ⅲ-Ⅳ |
42 43 |
26 26 |
16 17 |
0.892 | 27 25 |
15 18 |
0.561 | 21 18 |
21 25 |
0.451 |
| IPI 0-2 3-5 |
60 25 |
34 18 |
26 7 |
0.186 | 37 15 |
23 10 |
0.886 | 27 12 |
33 13 |
0.800 |
| Hans classification GCB Non-GCB |
17 68 |
9 43 |
8 25 |
0.436 | 7 45 |
10 23 |
0.059 | 5 34 |
12 34 |
0.128 |
| Ki-67 High Low |
57 28 |
36 16 |
21 12 |
0.593 | 34 18 |
23 10 |
0.680 | 26 13 |
31 15 |
0.944 |
| Relapse Yes No |
54 31 |
40 12 |
14 19 |
0.001 | 41 11 |
13 20 |
0.000 | 32 7 |
22 24 |
0.001 |
Notes: ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase; IPI, international prognostic index; GCB, germinal center B-cell-like lymphoma.