Table 5.
Prognostic factors and PFS/OS in DLBCL patients in test cohort treated with CHOP or CHOP-like regimen.
| Prognostic factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Progression-free survival | ||||||
| Age (≤60 vs. >60y.o.) | 3.806 | 1.687-8.588 | 0.001 | - | - | - |
| ECOG (<2 vs. ≥2) | 3.581 | 1.178-10.882 | 0.025 | - | - | - |
| LDH (normal vs. elevated) | 22.052 | 5.069-95.938 | 0.000 | 20.325 | 4.060-101.749 | 0.000 |
| Stage (Ⅰ-Ⅱ vs. Ⅲ-Ⅳ) | 5.843 | 2.470-13.822 | 0.000 | - | - | - |
| Extranodal sites (<2 vs. ≥2) | 3.622 | 1.585-8.279 | 0.002 | - | - | - |
| IPI (0-2 vs. 3-5) | 7.233 | 2.933-17.837 | 0.000 | 3.240 | 1.268-8.279 | 0.014 |
| B symptom (no vs. yes) | 3.246 | 1.496-7.044 | 0.003 | 3.130 | 1.231-7.957 | 0.017 |
| Bcl-2 expression (high vs. low) | 2.490 | 1.099-5.640 | 0.029 | 4.362 | 1.646-11.561 | 0.003 |
| Overall survival | ||||||
| Age (≤60 vs. >60y.o.) | 4.355 | 1.896-10.005 | 0.001 | - | - | - |
| ECOG (<2 vs. ≥2) | 4.707 | 1.466-15.108 | 0.009 | - | - | - |
| LDH (normal vs. elevated) | 35.585 | 4.753-266.397 | 0.001 | 32.220 | 4.259-243.736 | 0.001 |
| Stage (Ⅰ-Ⅱ vs. Ⅲ-Ⅳ) | 4.916 | 2.048-11.803 | 0.000 | - | - | - |
| Extranodal sites (<2 vs. ≥2) | 3.649 | 1.652-8.063 | 0.001 | - | - | - |
| IPI (0-2 vs. 3-5) | 6.134 | 2.692-13.973 | 0.000 | - | - | - |
| B symptom (no vs. yes) | 4.114 | 1.781-9.502 | 0.001 | 3.247 | 1.354-7.787 | 0.008 |
| Bcl-2 expression (high vs. low) | 2.363 | 1.000-5.588 | 0.050 | - | - | - |