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. Author manuscript; available in PMC: 2019 Jun 4.
Published in final edited form as: Cancer Res. 2012 Mar 21;72(9):2394–2404. doi: 10.1158/0008-5472.CAN-11-3115

Figure 2.

Figure 2.

Dithiolethiones inhibit NF-κB transcriptional activity. A, chemical structures of the dithiolethiones used in this study compared with ADT. B, H2S release from ACS-1 over 1200 seconds as measured by chemical potential electrode. C, MDA-MB-231 cells transiently transfected with an NF-κB luciferase reporter construct exposed to TNF-α (20 ng/mL) alone or in combination with ACS-1, ACS-2, NaSH, or VPA. Luciferase activity shown as mean RLU (± SD) was normalized to percent of TNF-α control activity.