TABLE 1.

Unadjusted and adjusted generalized estimating equation (GEE) models demonstrating associations of the short and long FMR1 alleles with ovarian response and assisted reproduction outcomes.

	FMR1 short allele				FMR1 long allele
Variable	Unadjusted association (95% CI)	P value	Adjusted association (95% CI)	P value	Unadjusted association (95% CI)	P value	Adjusted association (95% CI)	P value
Continuous
Gonadotropins (d)	−0.05 (−0.10 to −0.01)	.04	−0.02 (−0.05 to 0.01)	.10	−0.01 (−0.06 to 0.04)	.15	0.01 (−0.01 to 0.04)	.30
Gonadotropins (IU)	−25 (−43 to −9)	.003	−24 (−45 to −3)	.02	−11 (−25 to 4)	.14	−4 (−23 to 16)	.71
Estradiol (pg/mL)	17 (8–25)	< .001	10 (3–22)	.13	11 (4–18)	.001	10 (−2 to 22)	.11
Follicles	0.07 (0.03–0.11)	.002	0.07 (0.01–0.12)	.02	0.04 (0.01–0.07)	.02	0.05 (0.00–0.10)	.05
Oocytes retrieved	0.07 (0.01–0.14)	.02	0.08 (−0.01 to 0.16)	.06	0.05 (0.01–0.10)	.04	0.04 (−0.03 to 0.11)	.29
MII oocytes	0.06 (0.01–0.11)	.02	0.06 (−0.01 to 0.13)	.07	0.05 (0.01–0.09)	.02	0.06 (−0.01 to 0.11)	.08
Blastocysts (d5)	0.02 (0.01–0.04)	.01	−0.02 (−0.01 to 0.04)	.18	0.02 (0.01–0.03)	.01	0.01 (−0.01 to 0.03)	.45
Blastocysts (d6)	0.03 (0.01 −0.05)	.004	0.01 (−0.02 to 0.04)	.54	0.03 (0.01–0.05)	.02	0.01 (−0.01 to 0.04)	.29
Vitrified embryos	0.03 (0.01 −0.05)	.007	0.01 (−0.02 to 0.05)	.40	0.04 (0.01–0.06)	.002	0.01 (−0.01 to 0.04)	.29
	Unadjusted OR (95% CI)		Adjusted OR (95% CI)		Unadjusted OR (95% CI)		Adjusted OR (95% CI
Outcome
Good embryo grade	0.99 (0.97–1.01)	.43	1.00(0.98–1.02)	.96	0.99(0.97–1.01)	.24	1.00 (0.98–1.02)	.62
Blastocyst transfer	0.98 (0.97–1.01)	.13	1.00(0.97–1.03)	.91	0.99(0.97–1.01)	.10	1.01 (0.98–1.03)	.40
Live birth	0.98 (0.96–1.01)	.33	1.00(0.98–1.02)	.97	0.99(0.98–1.01)	.33	1.00 (0.99–1.01)	.85

Note: Continuous and dichotomous variables were adjusted for age, antimullerian hormone (AMH), antral follicle count (AFC), and follicle-stimulating hormone (FSH). Live birth was adjusted for age, AMH, AFC,FSH, and the number of embryos transferred.