Table 2.
Current Clinical Trials Based on Exosomes in Cancer
| Title | Recruitment | Cancer | Interventions |
|---|---|---|---|
| Exosomes as potential prognostic and predictive biomarkers | Unknown status | Gastric cancer | |
| Urinary exosome for cancer diagnosis | Completed | Prostate cancer | Other: ExoIntelliScore Prostate |
| Exosome-mediated intercellular signaling | Recruiting | Pancreatic cancer ∣ Benign pancreatic disease | |
| Vaccination trial with dendritic cell-derived exosomes | Unknown status | Nonsmall cell lung cancer | Biological: Dex2 |
| Plant exosomes to deliver curcumin to normal and cancer tissue | Active, not recruiting | Colon cancer | Dietary supplement: curcumin ∣ Dietary supplement: Curcumin conjugated with plant exosomes ∣ Other: No intervention |
| Edible plant exosome ability to prevent oral Recruiting mucositis associated with chemoradiation treatment | Head and neck cancer ∣ Oral mucositis | Dietary supplement: Grape extract ∣ Drug: Lortab, fentanyl patch, mouthwash | |
| Tumor-derived exosomes as diagnostic and Withdrawn prognostic markers | Breast neoplasms | ||
| Metformin hydrochloride affecting cytokines and exosomes in cancer | Recruiting | Larynx ∣ Lip ∣ Oral cavity ∣ Pharynx | Radiation: External beam radiation therapy ∣ Drug: Metformin hydrochloride ∣ Other: Placebo |
| Screening for human papillomaviruspositive oropharyngeal squamous cell carcinoma | Recruiting | Oropharyngeal cancer | |
| Diagnostic accuracy of circulating tumor cells (CTCs) and onco-exosome | Recruiting | Pancreatic ductal adenocarcinoma (PDAC) | Procedure: Blood samples ∣ Procedure: Portal vein blood sample |
| Consistency analysis of PD-L1 in cancer tissue and plasma exosome | Not yet recruiting | NSCLC | Other: Liquid biopsy |
| Consistency analysis of PD-L1 in lung cancer tissue and plasma exosome before and after radiotherapy | Not yet recruiting | NSCLC | Radiation: Radiotherapy |
| Circulating exosome RNA in lung metastases of primary high-grade osteosarcoma | Recruiting | Lung metastases ∣ Osteosarcoma | Other: Blood samples |
| Anaplastic thyroid cancer and follicular thyroid cancer-derived exosomal analysis via treatment of lovastatin and vildagliptin and Pilot Prognostic Study via urine exosomal biological markers in thyroid cancer patients | Not yet recruiting | Thyroid cancer | |
| ncRNAs in exosomes of cholangio carcinoma | Recruiting | Cholangiocarcinoma ∣ Benign biliary stricture |