Table 3.

List of exosomal miRNA of diagnostic significance identified in lung cancer

miRNA	Method of Study	Functional Role	References
miR-155, let-7a-2	miRNA-microarray	Differentiates lung cancer from noncancerous lung tissue	Yanaihara et al. (2006)
miR-17-3p, hsa-miR-21, hsa-miR-106a, hsa-miR-146, hsa-miR-155, hsa-miR-191, hsa-miR-192, hsa-miR-203, hsa-miR-205, hsa-miR-210, hsa-miR-212, and hsa-miR-214	miRNA-microarray	Validation of diagnostic miRNAs	Rabinowits, Gerçel-Taylor, Day, Taylor, and Kloecker (2009)
miR-29a-3p and miR-150-5p	Quantitative real-time polymerase chain reaction using Exqon miRNA expression profiling panel	Detection of response of radiotherapy in nonsmall cell lung cancer (NSCLC)	Dinh et al. (2016)
miR-21 and miR-155	miRNA-microarray	Differentiates recurrent tumors from primary tumors	Munagala, Aqil, and Gupta (2016) and Munagala, Aqil, Jeyabalan, and Gupta (2016)
miR-30b-5p, 30c-5p, 221-3p, 222-3p	miRNA-microarray	EGFR status	Giallombardo et al. (2016)
miR-19b-3p, miR-21-5p, miR-221-3p, miR-409-3p, miR-425-5p, and miR-584-5p	Quantitative real-time polymerase chain reaction using Exqon miRNA expression profiling panel	Biomarkers for lung adenocarcinoma detection	Cui et al. (2018)
miR-205-5p and miR-200b	Sequencing	Differentiates patients with lung cancer from patients with pneumonia and pulmonary tuberculosis	Lin et al. (2016)
miR-181-5p, miR-30a-3p, miR-30e-3p, and miR-361-5p and let-7, miR-21, miR-24, and miR-486	Seq	Identify NSCLC adenocarcinoma and squamous cell carcinoma	Jin et al. (2017)
miR-21 and miR-4257	miRNA-microarray	Predictive biomarkers for the recurrence of nonsmall cell lung cancer	Dejima, Iinuma, Kanaoka, Matsutani, and Kawamura (2017)