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. 2018 Dec 3;64(5):1238–1256. doi: 10.1007/s10620-018-5395-7

Table 1.

mRNA expression of Itgam, Emr1, and Tnfα from progression study

Itgam Emr1 Tnfα
CSAA CDAA CDAA +1%chol CDAA +2%chol CSAA CDAA CDAA +1%chol CDAA +2%chol CSAA CDAA CDAA +1%chol CDAA +2%chol
4 weeks 1.0 ± 0.2 17.4 ± 2.5 19.0 ± 2.8# 22.9 ± 3.5# 1.0 ± 0.1 3.1 ± 0.5# 4.1 ± 0.5# 3.9 ± 0.4# 1.0 ± 0.1 4.6 ± 0.8# 5.5 ± 0.9# 5.3 ± 0.6#
8 weeks 0.9 ± 0.2 15.0 ± 2.7 43.2 ± 5.4#*∆ 36.0 ± 3.6#* 0.7 ± 0.1 2.7 ± 0.4# 4.6 ± 0.3#* 4.8 ± 0.4#* 0.6 ± 0.2 3.5 ± 0.5# 7.7 ± 0.6#* 8.1 ± 0.6#*
12 weeks 1.7 ± 0.2 34.1 ± 4.7#∆$ 45.2 ± 5.3#∆ 52.3 ± 4.3#*∆ 1.3 ± 0.1 3.3 ± 0.4# 3.9 ± 0.3# 4.8 ± 0.2# 1.4 ± 0.4 7.9 ± 0.8#$ 9.9 ± 1.0#∆ 9.9 ± 0.7#∆
Acta2 Pai1 Ctgf
CSAA CDAA CDAA +1%chol CDAA +2%chol CSAA CDAA CDAA +1%chol CDAA +2%chol CSAA CDAA CDAA +1%chol CDAA +2%chol
4 weeks 1.0 ± 0.1 10.2 ± 1.4# 10.2 ± 1.5# 12.4 ± 1.2# 1.0 ± 0.3 11.7 ± 2.4 15.9 ± 2.9 20.6 ± 2.6 1.0 ± 0.2 9.8 ± 1.6 21.6 ± 3.6 27.8 ± 3.3#
8 weeks 0.8 ± 0.2 7.9 ± 1.3 16.7 ± 1.9#* 20.3 ± 3.0#* 1.1 ± 0.4 10.3 ± 2.2 32.4 ± 6.4# 36.2 ± 5.3# 1.7 ± 0.6 16.1 ± 3.6 47.1 ± 7.7#*∆ 51.1 ± 5.8#*∆
12 weeks 1.6 ± 0.2 20.0 ± 2.9#∆$ 19.5 ± 1.9#∆ 20.1 ± 2.4# 1.7 ± 0.7 32.9 ± 4.2# 55.0 ± 14.4#∆ 59.5 ± 13.0#∆ 2.4 ± 0.4 58.3 ± 5.4#∆$ 82.3 ± 6.3#*∆$ 67.4 ± 7.6#∆

#P < 0.05 versus CSAA, *P < 0.05 versus CDAA, P < 0.05 versus same diet at 4 weeks, $P < 0.05 versus same diet at 8 weeks