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. 2018 Dec 20;64(5):1158–1170. doi: 10.1007/s10620-018-5420-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 11 — Ussing chamber studies of mucosal barrier function in the jejunum after ileocecal resection. Jejunal tissues were stripped off the serosa and the muscularis. a Transmucosal electrical resistance (TMER) did not change in sham-operated mice (n = 4). At day 14, the jejunum of ICR mice displayed significantly higher TMER (n = 9; p < 0.05, Wilcoxon test). b Relative Na/Cl permeability, which is represented by epithelial tight junctions, was calculated from Na/Cl dilution potentials. Both after sham and after ICR, ion selectivity was unchanged (sham n = 6; ICR n = 9; p > 0.05, respectively) despite villus hypertrophy, which only occurred in ICR animals. c The paracellular leak pathway was studied by 4 kDa fluorescein isothiocyanate–dextran FITC 4-kDa dextran diffusion. At day 14, the permeability in sham-operated mice (n = 7) was not significantly changed. At day 14, permeability was numerically lower in ICR mice, although not statistically significant (n = 6; p = 0.16, Wilcoxon test)