Fig. 6.

Wellness score change predicts premature death. In surviving mice, the day-to-day wellness score change from 48 h to 24 h prior to visit was calculated for all days. In premature dying mice, the wellness score change from 48 h to 24 h before death was calculated. Mean change during the first 4 days was similar between survivors (n = 132, black) and dead mice (n = 11, light gray, p = 0.827). Thereafter, mean wellness score change for dead mice (n = 13, white) was significantly reduced compared to survivors (n = 327, dark gray). Mean + SEM, ***p < 0. 001, U test