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. 2018 Dec 26;28(12):1931–1946. doi: 10.1093/hmg/ddy449

Table 1.

Body weight, urine and blood parameters in Ocrl and Clcn5 mice

8 weeks 8 weeks 16 weeks 24 weeks 48 weeks
Ocrl Y/+ (n = 7) Ocrl Y/− (n = 7) Clcn5 Y/+ (n = 4) Clcn5 Y/− (n = 4) Ocrl Y/+ (n = 7) Ocrl Y/− (n = 7) Ocrl Y/+ (n = 7) Ocrl Y/− (n = 7) Ocrl Y/+ (n = 5) Ocrl Y/− (n = 5)
Body weight
(gr)		 24.6 ± 0.8 25.8 ± 0.4 31.03 ± 1.3 27.2 ± 1.2 31.3 ± 0.9 26.6 ± 0.9a 36.3 ± 0.9 32.2 ± 0.7a 40.1 ± 2.5 33.1 ± 1.8b
U volume
(μl/12 h)		 2267 ± 337 3122 ± 328 1400 ± 82 3025 ± 111c 2414 ± 298 3571 ± 561 2388 ± 650 2462 ± 544 1655 ± 315 2138 ± 555
Diuresis
(μl/gr BW/min)		 0.12 ± 0.02 0.16 ± 0.01 0.06 ± 0.004 0.15 ± 0.004b 0.1 ± 0.01 0.18 ± 0.03 0.09 ± 0.02 0.11 ± 0.02 0.06 ± 0.01 0.091 ± 0.02
U Albumin
(mg/gr creatinine)		 0.97 ± 0.3 21 ± 1.1c 3.3 ± 0.2 69 ± 13b 9.2 ± 2.3 27.9 ± 3.1c 11.8 ± 3.4 25.7 ± 2.1c 8.6 ± 2.5 39.5 ± 3.2c
U CC16
(mg/gr creatinine)		 0.14 ± 0.02 1.9 ± 0.2c 0.09 ± 0.02 19.2 ± 1.9c 0.03 ± 0.00 2.5 ± 0.3c 0.05 ± 0.01 2.9 ± 0.3c 0.06 ± 0.02 2.9 ± 0.2c
U calcium
(mg/gr creatinine)		 94.9 ± 6.4 73.9 ± 14.5 58.2 ± 16.4 144 ± 11.6b 135 ± 11.2 148 ± 14.3 70.4 ± 20.3 93.8 ± 8 148 ± 23 109 ± 11.5
U glucose
(mg/gr creatinine)		 1561 ± 136 1451 ± 95 1122 ± 76 1982 ± 341a 1440 ± 171 1418 ± 163 1081 ± 179 1672.7 ± 493 3040 ± 993 1534 ± 93
U phosphate
(mg/gr creatinine)		 4051 ± 419 4316 ± 160 2684 ± 314 4294 ± 448a 4436 ± 403 4017 ± 372 2584 ± 422 2761 ± 423 3072. ± 434 3101 ± 106
U creatinine
(mg/dl)		 26 ± 1.8 24 ± 1.5 31 ± 1.9 30 ± 2.5 23 ± 2.8 20 ± 1.9 35 ± 6.4 30 ± 3.8 25 ± 5 27 ± 1.9
BUN
(mg/dl)		 - - - - 22 ± 1.5 22 ± 1.3 - - 24 ± 2.7 22 ± 1.2
Plasma creatinine
(mg/dl)		 - - - - 0.09 ± 0.02 0.08 ± 0.006 - - 0.05 ± 0.007 0.06 ± 0.01

U, Urine; BUN, Blood urea nitrogen; BW, Body weight. All the measurements were performed on OcrlY/+ and OcrlY/− male mice matched per age.

Plotted data represent mean ± SEM. Two-tailed unpaired Student’s t-test was applied between genotypes for the indicated time point.

a P < 0.05 versus Ocrl Y/+ or Clcn5Y/+;

b P < 0.01 versus Ocrl Y/+or Clcn5Y/+;

c P < 0.001 versus Ocrl Y/+ or Clcn5Y/+.