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Oncogenic Ras promotes productive metabolism and blocks anoikis via divergent downstream effectors. During ECM-detachment, cells harboring oncogenic Ras mutations signal via a PI(3)K/SGK1-mediated pathway to increase glucose uptake, ATP generation, and survival (right, green box). Simultaneously, oncogenic Ras diminishes PHLPP1 levels to overcome p38 MAPK-mediated anoikis activation (left, red box).
