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. Author manuscript; available in PMC: 2019 Jul 26.
Published in final edited form as: Cell. 2018 Jun 7;174(3):744–757.e24. doi: 10.1016/j.cell.2018.05.024

Figure 2. SPRITE identifies higher-order interactions that occur simultaneously.

Figure 2

(A) Compartment eigenvector showing A (red) and B (blue) compartments on mouse chromosome 2 (Top). Individual SPRITE clusters (rows) containing reads mapping to at least 3 distinct regions (*) (Middle). Pairwise contact map at 200kb resolution (Bottom). (B) Schematic of multiple A compartment interactions. (C) H3K27ac ChIP-seq signal across a 2.46 Mb region on human chromosome 6 corresponding to 3 TADs containing 55 histone genes (Top). SPRITE clusters containing reads in all 3 TADs (Middle). Pairwise contact map at 25kb resolution (Bottom). (D) Schematic of higher-order interactions of HIST1 genes (green). (E) CTCF motif orientations at 3 loop anchors on human chromosome 8 (Top). SPRITE clusters overlapping all 3 loop anchors (Middle). Pairwise contact map at 25kb resolution (Bottom). (F) Schematic of higher-order interactions between consecutive loop anchors.