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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Nov 10;103(4):861–868. doi: 10.1016/j.ijrobp.2018.11.004

Table 2.

Comparison of progression-free and overall survival for patients enrolled in previous studies and our current study

Author Year Patients (N) Technique CTV Dose Marginal Failure PFS (%) OS (%)
3-y 5-y 6-y 8-y 10-y 3-y 5-y 6-y 8-y 10-y
Saran et al. [13] 2002 14 SRT GTV + 0.3–1.0 cm 50–55 Gy 0 87 100
Marcus et al. [12] 2005 50 SRT GTV 50–58 Gy 0 82.5 68 97.8 82
Merchant et al. [11] 2009 78 3D-CRT/IMRT GTV + 1.0 cm 54 Gy 1 87 74 98 96
Greenberger et al. [15] 2014 32 Proton GTV + 0.3 cm 52.2 RBE 90 83 100 100
Paulino et al. [14] 2013 39 IMRT GTV + 0.5–1.0 cm 50.4 Gy 0 78 94
Current study 2017 85 3D-CRT/IMRT GTV + 0.5 cm 54 Gy 0 77 71 94 93

Abbreviations: CTV, clinical target volume; 3D-CRT, three-dimensional conformal radiation therapy; GTV, gross target volume; IMRT, intensity-modulated radiation therapy; OS, overall survival; PFS, progression-free survival; RBE, relative biological effectiveness; SRT, stereotactic radiation therapy