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. Author manuscript; available in PMC: 2019 Jun 4.
Published in final edited form as: ACS Chem Neurosci. 2018 Dec 20;10(1):190–200. doi: 10.1021/acschemneuro.8b00572

Figure 2.

Figure 2

GPR88 signaling pathway. GPR88 couples to Gi/o proteins to inhibit adenylyl cyclase (AC) and reduce cAMP signaling and is likely an inhibitory receptor in the central nervous system.