Fig 2. Longitudinal maternal plasma abundance of MMP-7 and gpIIbIIIA in normal pregnancy and early preeclampsia.

Each line corresponds to a single patient (grey = normal pregnancy, red = early preeclampsia). Individual dots represent samples at 8–16 weeks (A, B) and 16.1–22 weeks (C, D) of gestation. Samples taken at the time of diagnosis with early preeclampsia are marked with an “x” and were not included in the analysis but only displayed. The thick black line represents the mean value in normal pregnancy. AUC: area under the receiver operating characteristic curve of the protein using data in the current interval; early PE: early preeclampsia; FC: fold change; gpIIbIIIa: glycoprotein IIb/IIIa; MMP-7: matrix metalloproteinase 7; MoM: multiples of the mean; p: the nominal significance p-value comparing mean MoM values between groups with a moderated t-test. Log₂FC is the log (base 2) of the fold change between the cases and control groups, with negative values denoting lower MoM values in cases than in controls.