Table 2. Summary of bootstrap results for prediction of early preeclampsia vs normal pregnancy.
| Outcome | Sample GA | AUC | Sensitivity | Specificity | Predictor Symbols (% inclusion in best combination) |
|---|---|---|---|---|---|
| (weeks) | |||||
| 8–16 | 0.64 | 0.31 | 0.90 | MMP-7(42%), gpIIbIIIa(23%), HMG-1(10%), vWF(10%) | |
| All | 16.1–22 | 0.88 | 0.71 | 0.90 | MMP-7(90%), gpIIbIIIa(18%), Soggy-1(10%), |
| Early PE | 22.1–28 | 0.90 | 0.81 | 0.90 | Siglec-6(58%), PlGF(52%), Activin A(25%), VEGF121(18%) |
| 28.1–32 | 0.94 | 0.85 | 0.90 | ALCAM(38%), VEGF121(32%), Siglec-6(32%) | |
| 8–16 | 0.63 | 0.32 | 0.90 | MMP-7(33%), gpIIbIIIa(26%), ACE2(18%) | |
| Early PE | 16.1–22 | 0.96 | 0.90 | 0.90 | MMP-7(99%), |
| MVM | 22.1–28 | 0.95 | 0.87 | 0.92 | Siglec-6(76%), PlGF(21%), Activin A(14%) |
| 28.1–32 | 0.95 | 0.90 | 0.90 | Siglec-6(63%), VEGF121(33%), ALCAM(10%) | |
| 8–16 | 0.67 | 0.35 | 0.90 | MMP-7(44%); gpIIbIIIa(17%); Glutathione S-transferase Pi(12%); SMAC(10%); C4b(10%) | |
| Early PE | 16.1–22 | 0.94 | 0.84 | 0.90 | MMP-7(97%); gpIIbIIIa(14%) |
| Severe | 22.1–28 | 0.89 | 0.81 | 0.91 | Siglec-6(68%); PlGF(34%); VEGF121(24%); Activin A(14%) |
| 28.1–32 | 0.95 | 0.88 | 0.90 | Siglec-6(52%); VEGF121(26%); ALCAM(22%) |
The number in parentheses following the name of each protein (column Predictor Symbols) represents the percentage of bootstrap iterations in which the protein was selected in the best model. Only proteins selected in 10% or more of the 200 bootstrap iterations are listed. ACE2: angiotensin converting enzyme 2; ALCAM: activated leukocyte cell adhesion molecule; AUC: area under the receiver operating characteristic curve; GA: gestational age; gpIIbIIIa: glycoprotein IIb/IIIa; HMG-1: high-mobility group protein 1; MMP: matrix metalloproteinase; early PE: early preeclampsia; MVM: maternal vascular malperfusion; PE: preeclampsia; PlGF: placental growth factor; Siglec-6: sialic acid binding immunoglobulin-like lectin; VEGF121: vascular endothelial growth factor A, isoform 121; vWF: von Willebrand factor; SMAC: Diablo homolog, mitochondrial; C4b: Complement C4b.