Fig 6. ArlRS–MgrA regulatory cascade controls adhesion under physiological conditions.

Adhesion of S. aureus GFP-expressing strains LAC (A-C) and MW2 (D) with the arlRS or mgrA deletions alone or with additional deletions of the giant surface proteins regulated by the ArlRS-MgrA cascade to fibrinogen (A), fibronectin (B), vWF (C), and collagen (D) was tested in flow chamber at the physiological shear of 10 dyn/cm². N = 10 per group. Additionally, adhesion of S. aureus strains LAC (E) and MW2 (F) to human plasma clot on orbital shaker (maximal shear ≈20 dyn/cm²) was measured, N = 6 per group. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, compared to WT. Data presented as mean ± SEM.