Table 2.

Neurotrophic polyphenolic signaling molecules

Compound	Model	Pathway	Neurotrophic factors	Function	References
Astilbin	Mouse	Erk, Akt	BDNF	Antidepressant-like effects	166
Butein	Mouse	Erk, CREB	BDNF	Cognitive Enhancement	167
CAPE	Mouse	Nrf2/ARE	BDNF	Protective of dopaminergic neurons	168
Curcumin	Rat	Akt/GSk-3β	BDNF	Reduced β-amyloid-induced cognitive impairment	169
Fisetin	Mouse	Erk, CREB	BDNF	Cognitive enhancement	167
Resveratrol	Rat	Erk, CREB	BDNF	Antidepressant-like effects	170,171
Rosmarinic acid	Rat	Erk	BDNF	Antidepressant-like effects	172

Table 2 shows seven naturally occurring plant-based polyphenolic compounds and their impact on six different physiologically relevant signaling pathways and their neurotrophic effects on BDNF. Also, shown are the experimental animal models used to demonstrate these effects. (Adapted from Moosavi et al.¹³). Molecular weights (in kD) for these compounds are as follows: astilbin, 0.450; butein, 0.272; CAPE, 0.284; curcumin, 0.368; fisetin, 0.286; resveratrol, 0.228; rosmarinic acid, 0.360

CAPE caffeic acid phenethyl ester, BDNF brain-derived neurotrophic factor