Table 1. Physicochemical parameters of ethyl 7-methoxy-3-(substituted benzoyl)-indolizine-1-carboxylate 5a–5j.
| Compound code | Mol formulae (Mol Mass) | R1 | R2 | Yield (%)a | m.p (°C) reported | m.p (°C) found | cLogPb |
|---|---|---|---|---|---|---|---|
| 5a | C20H16N2O4 (348) | 4-CN | H | 81 | 165 | 165 | 3.9570 |
| 5b | C21H18N2O4 (362) | 4-CN | CH3 | 74 | 191 | 192 | 4.4560 |
| 5c | C23H20N2O6 (420) | 4-CN | COOC2H5 | 79 | - | 171 | 3.4454 |
| 5d | C19H16FNO4 (341) | 4-F | H | 80 | 118 | 118 | 4.5293 |
| 5e | C20H18FNO4 (355) | 4-F | CH3 | 73 | 137 | 138 | 5.0283 |
| 5f | C22H20FNO6 (413) | 4-F | COOC2H5 | 79 | - | 147 | 4.0199 |
| 5g | C19H16BrNO4 (402) | 4-Br | H | 75 | 183 | 182 | 5.2493 |
| 5h | C20H18BrNO4 (416) | 4-Br | CH3 | 77 | 148 | 148 | 5.7483 |
| 5i | C20H19NO5 (353) | 3-OCH3 | H | 85 | 116 | 116 | 4.4986 |
| 5j | C23H23NO7 (425) | 3-OCH3 | COOC2H5 | 76 | - | 142 | 4.0294 |
a Yields calculated after purification by column chromatography.
b ChemDraw Professional 16 was used to calculate cLogP of the title compounds.