Table 3. In vitro whole-cell anti-TB activity of 7-methoxy-indolizine analogues (5a–j) against H37RV and MDR-MTB isolates.
Compound Code | Anti-TB activity—MIC (μg/mL) | |
---|---|---|
H37RV isolate | MDR-MTB isolate* | |
5a | 8 | 32 |
5b | NA | NA |
5c | 32 | 64 |
5d | 8 | NA |
5e | 32 | NA |
5f | 32 | NA |
5g | NA | NA |
5h | NA | NA |
5i | 8 | 16 |
5j | 8 | 16 |
MIC, minimum inhibitory concentration.
*These isolates were found to be resistant to the first-line antibiotics rifampicin (1 μg/mL), and isoniazid (0.2 μg/mL).
NA: not active