Table 5:

Major radiotherapy advancements in pediatric renal tumors

Intensified RT and chemotherapy improves survival for high-risk renal tumors Tumor rupture was upstaged to stage III and flank RT was recommended Whole lung RT can be safely omitted for stage IV favorable histology Wilms tumor with lung-only metastases and without LOH at 1p and 16q, who have a complete response to DD4A chemotherapy Whole lung RT with regimen M chemotherapy resulted in excellent survival for stage IV favorable histology Wilms tumor with had slow incomplete response to DD4A chemotherapy For patients with bilateral Wilms tumor, induction chemotherapy, timely surgical resection and response-based RT results in improved survival Cardiac sparing whole lung IMRT and liver IMRT with 4D simulation and central QA review will be studied in prospective clinical trials