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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Mar 14;101(4):860–874. doi: 10.1016/j.ijrobp.2018.03.002

Table 7.

ALL Risk Groups

Standard Risk: All of the following

  • Age 1–10 years

  • WBC < 50,000/mm3

  • B-cell phenotype

  • No or very few leukemia cells in spinal fluid

  • No VHR features

High Risk: Any of the following

  • Age ≥ 10 years

  • WBC > 50,000/mm3

  • T-cell phenotype

  • Spinal fluid with ≥ 5 WBC/hpf and detectable lymphoblasts

And: No VHR features
Very High Risk: Any of the following

  • High MRD at end of induction

  • Adverse cytogenetics
    • MLL gene rearrangement
    • Hypodiploidy