Table 3.
Percent difference in post-pregnancy biomarkers and 95% confidence intervals among women with no history of HDP, comparing women with only term deliveries to women with a history of preterm deliveries
| Only Term (≥37 weeks) | Ever Preterm (<37 weeks) | Ever Moderate Preterm (≥32 to <37 weeks) | Ever Very Preterm (<32 weeks) | |
|---|---|---|---|---|
| CRP | n=2,096 | n=258 | n=200 | n=58 |
| CRP level, mg/L, median (IQR) | 0.78 (0.35, 1.94) | 0.77 (0.39, 1.63) | 0.76 (0.38, 1.70) | 0.86 (0.40, 1.56) |
| Model 1 | ref | −3.5 (−15.5, 10.2) | −1.5 (−14.8, 13.9) | −10.2 (−32.5, 19.5) |
| Model 2 | ref | −2.9 (−14.9, 10.8) | −0.9 (−14.3, 14.5) | −9.4 (−31.7, 20.3) |
| IL-6 | n=1,986 | n=253 | n=197 | n=56 |
| IL-6 level, pg/mL, median (IQR) | 0.89 (0.63, 1.37) | 0.89 (0.61, 1.39) | 0.87 (0.59, 1.33) | 0.96 (0.76, 1.52) |
| Model 1 | ref | 0.0 (−8.2, 9.0) | −2.9 (−11.6, 6.7) | 11.0 (−7.8, 33.6) |
| Model 2 | ref | 0.3 (−8.1, 9.3) | −2.6 (−11.5, 7.2) | 11.1 (−7.5, 33.4) |
| HbA1C | n=706 | n=84 | n=65 | n=19 |
| HbA1C, %, median (IQR) | 5.38 (5.21, 5.53) | 5.41 (5.24, 5.53) | 5.42 (5.21, 5.53) | 5.38 (5.26, 5.53) |
| Model 1 | ref | 0.2 (−0.8, 1.2) | 0.2 (−0.9, 1.4) | 0.2 (−1.2, 1.6) |
| Model 2 | ref | 0.2 (−0.8, 1.1) | 0.2 (−1.0, 1.3) | 0.1 (−1.3, 1.5) |
| ICAM-1 | n=990 | n=126 | n=93 | n=33 |
| ICAM-1, ng/mL, median (IQR) | 231.9 (208.3, 260.1) | 231.2 (203.6, 265.5) | 225.8 (201.3, 262.9) | 246.1 (220.7, 278.6) |
| Model 1 | ref | 1.7 (−2.2, 5.7) | 0.3 (−4.0, 4.8) | 5.5 (−2.2, 13.8) |
| Model 2 | ref | 1.6 (−2.3, 5.6) | 0.6 (−3.8, 5.1) | 4.4 (−3.2, 12.6) |
| HDL-C | n=743 | n=90 | n=70 | n=20 |
| HDL-C level, mg/dL, median (IQR) | 58.7 (50.6, 68.7) | 59.5 (51.7, 70.8) | 59.7 (51.4, 71.0) | 57.1 (52.1, 70.5) |
| Model 1 | ref | 2.5 (−2.9, 8.1) | 1.8 (−4.3, 8.2) | 4.9 (−5.0, 15.7) |
| Model 2 | ref | 2.7 (−2.7, 8.4) | 2.1 (−4.0, 8.5) | 5.1 (−5.1, 16.3) |
| LDL-C | n=743 | n=90 | n=70 | n=20 |
| LDL-C level, mg/dL, median (IQR) | 111.3 (92.0, 130.0) | 112.8 (96.3, 131.2) | 111.3 (94.6, 126.1) | 117.3 (106.9, 135.4) |
| Model 1 | ref | 2.9 (−2.2, 8.3) | 2.1 (−3.7, 8.3) | 5.9 (−2.9, 15.5) |
| Model 2 | ref | 2.5 (−2.6, 7.8) | 1.7 (−4.0, 7.9) | 5.1 (−3.5, 14.4) |
| Triglycerides | n=1,133 | n=141 | n=108 | n=33 |
| Triglycerides, mg/dL, median (IQR) | 85.3 (65.0, 122.1) | 85.0 (61.6, 117.3) | 83.8 (61.3, 114.8) | 100.7 (70.2, 134.7) |
| Model 1 | ref | −4.4 (−12.0, 3.8) | −6.7 (−15.2, 2.7) | 3.6 (−10.1, 19.4) |
| Model 2 | ref | −4.2 (−11.7, 3.9) | −6.3 (−14.8, 3.0) | 3.1 (−10.3, 18.5) |
| Total Cholesterol | n=2,360 | n=292 | n=218 | n=74 |
| Total Cholesterol, mg/dL, median (IQR) | 190.2 (170.2, 214.2) | 193.0 (175.8, 213.8) | 192.3 (173.5, 213.6) | 199.4 (182.9, 217.7) |
| Model 1 | ref | 0.8 (−1.1, 2.7) | 0.2 (−2.0, 2.4) | 2.5 (−1.1, 6.2) |
| Model 2 | ref | 0.7 (−1.2, 2.6) | 0.2 (−2.0, 2.4) | 2.1 (−1.4, 5.8) |
Model 1 is adjusted for the following criteria for sample selection for laboratory analysis: age at blood draw, race, menopausal status at blood draw, smoking at blood draw, alcohol intake at blood draw, post-menopausal hormone use at blood draw, and history of infertility at blood draw.
Model 2 is additionally adjusted for pre-pregnancy BMI, diet, and physical activity, and parity at blood draw.
The null value comparing ever preterm groups to only term is 0.0 percent difference.