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. Author manuscript; available in PMC: 2019 Jun 4.
Published in final edited form as: Bioconjug Chem. 2018 Nov 7;29(11):3776–3782. doi: 10.1021/acs.bioconjchem.8b00640

Figure 2.

Figure 2.

Stability of PARPi-FL NE. (a) SEC of PARPi-FL NE over 24 h at 37°C in human serum. (b) Amount of PARPi-FL NE remaining intact and amount of PARPi-FL molecule over 24 h at 37°C in human serum. (c) Blood half-life of PARPi-FL NE (0.39 mM, 78 nmol of PARPi-FL in 200 μL of PBS) in mice (n = 3) had their original concentration decreased by half in 6 h.