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. 2019 May 14;11(3):51–64. doi: 10.1080/19382014.2019.1601490

Figure 3.

Figure 3.

Effect of blockade of CPT1 and PA on OCR and ISR in the presence of high (A) and low (B) glucose. Islets were perifused in the presence of 3 mM glucose for 90 min. Islets were then exposed to etomoxir (200 µM) for 45 min and both etomoxir and PA (100 µM) for 45 min either after (A) or before (B) glucose was increased to 20 mM for 45 min. OCR and ISR were measured concomitantly using the flow culture system. Steady-state values of OCR and ISR at 3 mM glucose were 0.41 ± 0.056 nmol/min/100 islets (n = 7) and 0.14 ± 0.059 ng/min/100 islets (n = 7), respectively for the sets shown in A, and 0.50 ± 0.040 nmol/min/100 islets (n = 8) and 0.24 ± 0.064 ng/min/100 islets (n = 8), respectively for the sets shown in B. Data are displayed and processed as described in the legend of Figure 1.