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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nat Genet. 2019 May 1;51(5):815–823. doi: 10.1038/s41588-019-0395-x

Figure 4. CHMP4C splicing is associated with EOC risk allele.

Figure 4.

a. Schematic of the splicing assay, CHMP4C exon 3 with flanking intronic sequence was cloned into a splicing reporter vector. Plasmids were generated to harbor either the ‘G’ or ‘A’ allele of the SNP. b. In FUOV1 ovarian cancer cells the ‘A’ allele is associated with higher rates of exon inclusion. PSI, percent spliced in. Data shown are mean with SD from N = 4 independent experiments, ** P =0.0024, two-tailed paired Student’s T-test.